William B. Grant,
Ph.D.
Sunlight,
Nutrition, and Health
Research Center
(SUNARC)
Table 1. Evidence by disease. Abbreviations:
Status: D, draft; (d),
started, R, reviewed; S, submitted; ?, will omit during first round; PubM
T&A as of Feb. 11, 2011, updated August 8, pubmed.gov, words in title
and/or abstract; ecol, ecological studies, obser, observational studies, RCT,
randomized controlled trial (or used in treatment with positive results); mod,
moderate; assoc, effects of low vitamin D due to comorbid diseases or treatment.
Disease
|
Status
|
PubM
2-11
|
PM
8-8
|
Ecol
|
Obser
|
RCT
|
Strong
|
Mod
|
Weak
|
Assoc
|
Acne
|
D
|
14
|
15
|
|
|
|
|
|
|
X
|
Amyotrophic
lateral sclerosis
|
S
|
7
|
7
|
|
|
|
|
|
X
|
|
Anaphylaxis,
food allergy
|
RS
|
7
|
8
|
X
|
X
|
|
|
X
|
|
|
Anemia
|
S
|
150
|
165
|
|
X
|
X
|
X
|
|
|
|
Ankylosing spondylitis
|
D
|
22
|
22
|
|
|
|
|
|
|
X
|
Anxiety
|
D
|
26
|
30
|
|
|
|
|
|
X
|
|
Asthma
|
RS
|
106
|
134
|
|
X
|
X
|
|
X
|
|
|
Atopic
dermatitis, eczema
|
S
|
23
|
24
|
|
X
|
X
|
|
X
|
|
|
Atherosclerosis
|
S
|
142
|
158
|
|
X
|
|
X
|
|
|
|
Autism
|
RS
|
18
|
21
|
X
|
X
|
|
X
|
|
|
|
Bacterial
vaginosis
|
S
|
5
|
7
|
|
X
|
|
X
|
|
|
|
Benign prostate
hyperplasia
|
D
|
14
|
12
|
|
X
|
|
|
|
X
|
|
Biliary cirrhosis, primary (PBC)
|
D
|
99
|
101
|
X
|
|
|
|
X
|
|
|
Birth defects
|
?
|
6
|
6
|
|
|
|
|
|
X
|
|
Disease
|
|
PubM
2-11
|
PM*
8-8
|
Ecol
|
Obser
|
RCT
|
Strong
|
Mod
|
Weak
|
Assoc
|
15Bronchitis
|
?
|
2
|
2
|
|
|
|
|
|
|
|
Cancer
|
RS
|
2321
|
2485
|
X
|
X
|
X
|
X
|
|
|
|
Bladder
|
RS
|
43
|
21/43
|
X
|
|
|
X
|
|
|
|
Brain
|
D
|
17
|
0/19
|
X
|
|
|
|
X
|
|
|
Breast
|
RS
|
630
|
540/667
|
X
|
|
|
X
|
|
|
|
Cervical
|
S
|
17
|
9/18
|
X
|
|
|
|
|
|
|
|
S
|
|
228/339
|
|
|
|
|
|
|
|
20Colorectal
|
S
|
391
|
244
|
X
|
|
|
X
|
|
|
|
Endometrial
|
S
|
27
|
18/29
|
X
|
|
|
X
|
|
|
|
Esophageal
|
S
|
14
|
6/17
|
X
|
|
|
X
|
|
|
|
Eye (uveal)
|
?
|
10
|
3/8
|
|
|
|
|
|
|
|
Gallbladder
|
D
|
8
|
2/8
|
X
|
|
|
X
|
|
|
|
Gastric
|
RS
|
27
|
15/29
|
X
|
|
|
X
|
|
|
|
Head & neck
|
|
|
5/21
|
|
|
|
|
|
|
|
Hodgkin disease
|
S
|
27
|
|
X
|
|
|
X
|
|
|
|
Leukemia
|
S
|
301
|
306
|
X
|
|
|
|
X
|
|
|
Liver
|
?
|
55
|
3/59
|
|
|
|
|
|
|
|
Lymphoma
|
|
|
94
|
|
|
|
|
|
|
|
Lung
|
RS
|
91
|
56/99
|
X
|
|
|
|
X
|
|
|
32Melanoma
|
RS
|
145
|
166
|
X
|
|
|
|
X
|
|
|
Multiple myeloma
|
S
|
57
|
61
|
|
X
|
|
|
|
X
|
|
Non-Hodgkin’s lymphoma
|
S
|
22
|
24
|
X
|
|
|
X
|
|
|
|
Non-melanoma skin
|
D
|
~70
|
16
|
|
|
|
|
|
|
|
Ovarian
|
RS
|
85
|
60/94
|
X
|
|
|
X
|
|
|
|
Pancreatic
|
RS
|
56
|
43/60
|
X
|
|
|
|
X
|
|
|
Prostate
|
S
|
650
|
577/688
|
X
|
|
|
|
X
|
|
|
Rectal
|
S
|
|
30/65
|
|
|
|
|
|
|
|
Renal
|
RS
|
120
|
6/121
|
X
|
|
|
X
|
|
|
|
Vulvar
|
?
|
1
|
0/2
|
X
|
|
|
X
|
|
|
|
* for cancer, the first number is a search
using “vitamin D” and “breast cancer” while the second number is a search using
“vitamin D”, “breast” and “cancer”
Disease
|
|
PubM
2-11
|
PM
8-8
|
Ecol
|
Obser
|
RCT
|
Strong
|
Mod
|
Weak
|
Assoc
|
42Cardiac arrhythmia
|
?
|
20
|
2
|
|
|
|
|
|
|
|
Cardiovascular (disease)
|
RS
|
839
|
979
|
|
X
|
|
X
|
|
|
|
Celiac disease
|
D
|
80
|
86
|
|
|
|
|
|
|
X
|
Chronic kidney
failure
|
S
|
563
|
627
|
|
X
|
|
X
|
|
|
|
Chronic liver
disease
|
D
|
51
|
51
|
|
|
|
|
|
X
|
X
|
Chronic, diffuse
muscle pain
|
?
|
20
|
?
|
|
|
|
|
|
|
|
Chronic
obstructive pulmonary disease
|
RS
|
41
|
48
|
|
X
|
|
|
X
|
|
|
Cognitive
impairment
|
RS
|
26
|
28
|
|
X
|
|
|
X
|
|
|
50Common cold
|
D
|
|
|
|
|
X
|
|
X
|
|
|
(Congestive)
heart failure
|
RS
|
127
|
141
|
|
X
|
|
|
X
|
|
|
Coronary heart
disease
|
RS
|
53
|
59
|
|
X
|
|
X
|
|
|
|
Craniotabes
|
D
|
19
|
20
|
|
|
|
|
|
|
|
Cystic fibrosis
|
D
|
102
|
106
|
|
X
|
X
|
|
|
X
|
|
Dementia
|
D
|
58
|
66
|
|
|
|
|
|
X
|
|
Dental caries
|
RS
|
36
|
36
|
X
|
X
|
|
X
|
|
|
|
Depression
|
S
|
150
|
163
|
|
X
|
|
|
X
|
|
|
Diabetes, type 1
|
S
|
196
|
|
|
X
|
|
|
X
|
|
|
Diabetes, type 2
|
S
|
904
|
|
|
X
|
|
X
|
|
|
|
Diabetes
|
|
|
1006
|
|
|
|
|
|
|
|
60Epilepsy
|
D
|
90
|
100
|
|
X
|
|
|
|
X
|
X
|
Fabry disease
|
?
|
3
|
3
|
|
|
|
|
|
|
|
Falls, fractures
(under osteoporosis)
|
(d)
|
116
|
263
|
|
X
|
X
|
X
|
|
|
|
Fertility,
regular menses
|
(d)
|
46
|
48
|
|
X
|
|
|
X
|
|
X
|
Fibromyalgia
|
S
|
19
|
23
|
|
X
|
X
|
|
|
X
|
|
Gaucher disease
|
?
|
6
|
6
|
|
|
|
|
|
|
|
Headache,
tension
|
D
|
16
|
16
|
|
X
|
|
|
X
|
|
|
Hepatitis
|
|
83
|
92
|
|
|
|
|
|
|
|
HIV/AIDS
|
S
|
115
|
135
|
X
|
X
|
X
|
|
X
|
|
|
Hypercalcemia
|
|
1175
|
1205
|
|
|
|
|
|
|
|
70Hypertension
|
S
|
430
|
476
|
X
|
X
|
X
|
|
X
|
|
|
Inflammatory
bowel disease (Crohn’s disease, ulcerative colitis)
|
S
|
150
|
152
|
X
|
X
|
|
X
|
|
|
X
|
Influenza
|
RS
|
37
|
42
|
X
|
X
|
X
|
X
|
|
|
|
Insulin
resistance
|
|
152
|
185
|
|
X
|
X
|
X
|
|
|
|
Kidney stones
|
|
43
|
44
|
|
|
|
|
|
|
X
|
Learning (disorders)
|
?
|
0
|
21
|
|
|
|
|
|
|
|
Leprosy
|
?
|
15
|
18
|
|
|
|
|
|
|
|
Lupus
|
|
114
|
125
|
|
|
|
|
|
|
X
|
Meningococcal
dis., meningitis
|
S
|
0
|
4
|
X
|
|
|
X
|
|
|
|
Multiple
sclerosis
|
RS
|
306
|
366
|
|
X
|
|
X
|
|
|
|
80Muscular
weakness
|
|
146
|
|
|
X
|
|
|
|
|
|
Myopathy
|
|
|
84
|
|
|
|
X
|
|
|
|
Myositis
|
?
|
7
|
9
|
|
|
|
|
|
|
|
Neutropenia
|
?
|
9
|
9
|
|
|
|
|
|
|
|
Osteitis
deformans
|
?
|
0
|
0
|
|
|
|
|
|
|
|
Osteoarthritis
|
|
101
|
105
|
|
|
|
|
|
X
|
|
Osteomalacia
|
D
|
1189
|
1198
|
|
|
|
|
|
|
|
Osteopenia
|
|
652
|
678
|
|
|
|
|
|
|
|
Osteoporosis
|
S
|
3302
|
3448
|
|
X
|
X
|
X
|
|
|
|
Paget’s bone disease
|
S
|
74
|
58
|
|
X
|
X
|
|
X
|
|
|
90Pancreatitis
|
|
36
|
39
|
|
|
|
|
|
|
|
Parkinson’s
disease
|
RS
|
36
|
43
|
|
X
|
|
|
X
|
|
|
Pelvic floor
status
|
?
|
2
|
2
|
|
|
|
|
|
|
|
Periodontal
disease
|
RS
|
56
|
64
|
|
X
|
|
|
X
|
|
|
94Peripheral
vascular disease
|
RS
|
9
|
12
|
|
X
|
|
|
X
|
|
|
Pneumonia
|
RS
|
30
|
37
|
X
|
|
X
|
X
|
|
|
|
Polycystic ovary
syndrome
|
D
|
13
|
18
|
|
X
|
X
|
X
|
|
|
|
Preeclampsia
|
RS
|
29
|
38
|
|
X
|
|
X
|
|
|
|
Premature birth
and low birth weight, birthweight
|
|
68
|
165
|
|
|
|
|
|
|
|
Psoriasis, psoriatic arthritis
|
S
|
355
|
371
|
|
|
X
|
|
X
|
|
|
100Renal failure
|
|
803
|
822
|
|
|
|
|
|
|
|
Renal
osteodystrophy
|
|
341
|
344
|
|
|
|
|
|
|
|
Respiratory
tract infections
|
S
|
|
18
|
|
|
|
|
|
|
|
Rheumatoid
arthritis
|
|
214
|
222
|
|
X
|
|
|
|
|
X
|
Rickets
|
|
2110
|
2155
|
|
|
X
|
X
|
|
|
|
Rosacea
|
S
|
|
6
|
|
|
|
|
|
|
X
|
Schizophrenia
|
|
68
|
73
|
X
|
|
|
|
X
|
|
|
Seasonal
affective disorder
|
?
|
7
|
8
|
|
|
|
|
|
|
|
Sepsis/septicemia
|
RS
|
34
|
40
|
X
|
X
|
|
X
|
|
|
|
Sickle cell
disease
|
|
17
|
20
|
|
|
|
|
|
|
X
|
110Spinal
stenosis
|
?
|
6
|
6
|
|
|
|
|
|
|
|
Stroke
|
D
|
96
|
106
|
|
X
|
|
|
X
|
|
|
Systemic
sclerosis
|
?
|
14
|
15
|
|
|
|
|
|
|
|
Thalassaemia
|
|
14
|
16
|
|
|
|
|
|
|
|
Thrombosis
|
?
|
31
|
32
|
|
X
|
|
|
X
|
|
|
Tonsillitis
|
S
|
2
|
2
|
|
|
|
|
X
|
|
|
Tuberculosis
|
|
243
|
259
|
|
X
|
X
|
X
|
|
|
|
Turner syndrome
|
?
|
5
|
5
|
|
|
|
|
|
|
|
118Vitiligo
vulgaris
|
?
|
3
|
27
|
|
|
|
|
|
|
None
|
Total, D or S
|
73
|
|
|
|
|
|
|
|
|
|
Started
|
2
|
|
|
|
|
|
|
|
|
|
Left to complete
|
21
|
|
|
|
|
|
|
|
|
|
Omit in first round
|
22 (?)
|
|
|
|
|
|
|
|
|
|
Disease
|
118
|
PubM
2-11
|
PM
8-8
|
Ecol
|
Obser
|
RCT
|
Strong
|
Mod
|
Weak
|
Assoc
|
Status: D, draft;
R, reviewed; S, submitted; PubM T&A as of Feb. 11, 2011, pubmed.gov, words
in title and/or abstract; ecol, ecological studies, obser, observational
studies, RCT, randomized controlled trial (or used in treatment with positive
results); mod, moderate; assoc, effects of low vitamin D due to comorbid
diseases or treatment
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