Summary of evidence for a role of vitamin D in risk of disease incidence or death for 118 diseases or conditions.

William B. Grant, Ph.D.
Sunlight, Nutrition, and Health Research Center (SUNARC)
P.O. Box 641603
San Francisco, CA 94164-1603, USA                     
www.sunarc.org           


Table 1. Evidence by disease. Abbreviations:
Status: D, draft; (d), started, R, reviewed; S, submitted; ?, will omit during first round; PubM T&A as of Feb. 11, 2011, updated August 8, pubmed.gov, words in title and/or abstract; ecol, ecological studies, obser, observational studies, RCT, randomized controlled trial (or used in treatment with positive results); mod, moderate; assoc, effects of low vitamin D due to comorbid diseases or treatment.

Disease
Status
PubM
2-11
PM
8-8
Ecol
Obser
RCT
Strong
Mod
Weak
Assoc
Acne
D
14
15






X
Amyotrophic lateral sclerosis
S
7
7





X

Anaphylaxis, food allergy
RS
7
8
X
X


X


Anemia
S
150
165

X
X
X



Ankylosing spondylitis
D
22
22






X
Anxiety
D
26
30





X

Asthma
RS
106
134

X
X

X


Atopic dermatitis, eczema
S
23
24

X
X

X


Atherosclerosis
S
142
158

X

X



Autism
RS
18
21
X
X

X



Bacterial vaginosis
S
5
7

X

X



Benign prostate hyperplasia
D
14
12

X



X

Biliary cirrhosis, primary (PBC)                                       
D
99
101
X



X


Birth defects
?
6
6





X




Disease

PubM
2-11
PM*
8-8
Ecol
Obser
RCT
Strong
Mod
Weak
Assoc
15Bronchitis
?
2
2







Cancer
RS
2321
2485
X
X
X
X



Bladder
RS
43
21/43
X


X



Brain
D
17
0/19
X



X


Breast
RS
630
540/667
X


X



Cervical
S
17
9/18
X






Colon
S

228/339







20Colorectal
S
391
244
X


X



Endometrial
S
27
18/29
X


X



Esophageal
S
14
6/17
X


X



Eye (uveal)
?
10
3/8







Gallbladder
D
8
2/8
X


X



Gastric
RS
27
15/29
X


X



Head & neck


5/21







Hodgkin disease
S
27

X


X



Leukemia
S
301
306
X



X


Liver
?
55
3/59







Lymphoma


94







Lung
RS
91
56/99
X



X


32Melanoma
RS
145
166
X



X


Multiple myeloma
S
57
61

X



X

Non-Hodgkin’s lymphoma
S
22
24
X


X



Non-melanoma skin
D
~70
16







Ovarian
RS
85
60/94
X


X



Pancreatic
RS
56
43/60
X



X


Prostate
S
650
577/688
X



X


Rectal
S

30/65







Renal
RS
120
6/121
X


X



Vulvar
?
1
0/2
X


X



* for cancer, the first number is a search using “vitamin D” and “breast cancer” while the second number is a search using “vitamin D”, “breast” and “cancer”
Disease

PubM
2-11
PM
8-8
Ecol
Obser
RCT
Strong
Mod
Weak
Assoc
42Cardiac arrhythmia
?
20
2







Cardiovascular (disease)
RS
839
979

X

X



Celiac disease
D
80
86






X
Chronic kidney failure
S
563
627

X

X



Chronic liver disease
D
51
51





X
X
Chronic, diffuse muscle pain
?
20
?







Chronic obstructive pulmonary disease
RS
41
48

X


X


Cognitive impairment
RS
26
28

X


X


50Common cold
D




X

X


(Congestive) heart failure
RS
127
141

X


X


Coronary heart disease
RS
53
59

X

X



Craniotabes
D
19
20







Cystic fibrosis
D
102
106

X
X


X

Dementia
D
58
66





X

Dental caries
RS
36
36
X
X

X



Depression
S
150
163

X


X


Diabetes, type 1
S
196


X


X


Diabetes, type 2
S
904


X

X



Diabetes


1006







60Epilepsy
D
90
100

X



X
X
Fabry disease
?
3
3







Falls, fractures (under osteoporosis)
(d)
116
263

X
X
X



Fertility, regular menses
(d)
46
48

X


X

X
Fibromyalgia
S
19
23

X
X


X

Gaucher disease
?
6
6







Headache, tension
D
16
16

X


X


Hepatitis

83
92







HIV/AIDS
S
115
135
X
X
X

X


Hypercalcemia

1175
1205







70Hypertension
S
430
476
X
X
X

X


Inflammatory bowel disease (Crohn’s disease, ulcerative colitis)
S
150
152
X
X

X


X
Influenza
RS
37
42
X
X
X
X



Insulin resistance

152
185

X
X
X



Kidney stones

43
44






X
Learning (disorders)
?
0
21







Leprosy
?
15
18







Lupus

114
125






X
Meningococcal dis., meningitis
S
0
4
X


X



Multiple sclerosis
RS
306
366

X

X



80Muscular weakness

146


X





Myopathy


84



X



Myositis
?
7
9







Neutropenia
?
9
9







Osteitis deformans
?
0
0







Osteoarthritis

101
105





X

Osteomalacia
D
1189
1198







Osteopenia

652
678







Osteoporosis
S
3302
3448

X
X
X



Paget’s bone disease
S
74
58

X
X

X


90Pancreatitis

36
39







Parkinson’s disease
RS
36
43

X


X


Pelvic floor status
?
2
2







Periodontal disease
RS
56
64

X


X


94Peripheral vascular disease
RS
9
12

X


X


Pneumonia
RS
30
37
X

X
X



Polycystic ovary syndrome
D
13
18

X
X
X



Preeclampsia
RS
29
38

X

X



Premature birth and low birth weight, birthweight

68
165







Psoriasis, psoriatic arthritis
S
355
371


X

X


100Renal failure

803
822







Renal osteodystrophy

341
344







Respiratory tract infections
S

18







Rheumatoid arthritis

214
222

X




X
Rickets

2110
2155


X
X



Rosacea
S

6






X
Schizophrenia

68
73
X



X


Seasonal affective disorder
?
7
8







Sepsis/septicemia
RS
34
40
X
X

X



Sickle cell disease

17
20






X
110Spinal stenosis
?
6
6







Stroke
D
96
106

X


X


Systemic sclerosis
?
14
15







Thalassaemia

14
16







Thrombosis
?
31
32

X


X


Tonsillitis
S
2
2




X


Tuberculosis

243
259

X
X
X



Turner syndrome
?
5
5







118Vitiligo vulgaris
?
3
27






None
Total, D or S
73









Started
2









Left to complete
21









Omit in first round
22 (?)









Disease
118
PubM
2-11
PM
8-8
Ecol
Obser
RCT
Strong
Mod
Weak
Assoc

Status: D, draft; R, reviewed; S, submitted; PubM T&A as of Feb. 11, 2011, pubmed.gov, words in title and/or abstract; ecol, ecological studies, obser, observational studies, RCT, randomized controlled trial (or used in treatment with positive results); mod, moderate; assoc, effects of low vitamin D due to comorbid diseases or treatment


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